Food Chain Signals

2. Food Chain Signals Determine Hunger and Satiety, Sickness and Health
George A. Scheele, M.D.
December 15, 2015


Food chain signals are intimately involved in the evolution of vertebrates and mammals as they control the feedback mechanisms of hunger and satiety, which are important in reproduction and evolution. Without understanding the importance of hunger and satiety signals modern societies will suffer from epidemics of diet-related metabolic disease, including obesity, type 2 diabetes, lipid disorders, cardiovascular disease, brain disease, autoimmune disorders, and cancer.

A full understanding of satiety and hunger signals in the food chain will provide modern societies with the intellectual tools to optimize health and avoid the expanding epidemics of chronic degenerative disease, including the Metabolic Syndrome, which is associated with the metabolic diseases described above. The Institute to Improve World Health has achieved a breakthrough in understanding food chain signals that impact on multiple diseases that afflict the modern world.

The activities of the Institute to Improve World Health will show the breakthrough interplay of basic science discoveries with healthcare solutions that have the potential to stem the tide of metabolic disease in today’s world. Only through the integration of cell biology, molecular biology and molecular medicine, together with genomics and proteomics, can we solve the enormous problems of today’s malnutrition for the benefit of world health and productivity.


Factor4 has the ability to correct the deficiencies in the food chain caused by the combination of poor nutrition, the food Industry, the beverage industry, and the pharmaceutical Industry.


The La Jolla Project, supported by the Institute to Improve World Health, represents the #1 opportunity to convert the structural information of the Human Genome Project into functional information that will have direct, meaningful impact on the health and disease of the people around the world.

The proposed project has the following distinct advantages:

  • It is a doable project in that there are no technological limitations to the rapid completion of Specific Aim #1 in 3 to 5 years.
  • The budget of the project is modest in absolute terms and miniscule in terms related to the direct impact on health care costs.
  • The project, which harnesses structural aspects of the human genome and functional aspects of human biology, will provide important information that defines the role of early protein deficiencies in preventable metabolic disease.
  • It will provide a wealth of functional information that may explain many of the causes of chronic diseases associated with the Metabolic Syndrome. It is estimated that these chronic degenerative diseases are responsible for up to 80% of aging health care costs.
  • It will provide important information that will stimulate efforts to construct a map of all metabolic pathways in the human body and pinpoint which of these pathways, including their individual steps, will be impaired by diets that are low in protein that lead to metabolic disease, loss of human productivity, accelerated aging and premature death.
  • It will revolutionize the dietary recommendations that regulatory bodies publish on healthy diets around the world.
  • The ultimate impact will be on substantially lowering the health care costs across America, so that these costs, which currently represent almost 18% of the GDP may possibly be lowered to 10% of GDP or even less.
  • In short, this is the project that will have the greatest impact on the health of people around the world.
  • This proposal is also “smart” in that it leverages the $3 billion that was spent to sequence the human genome and the mountain of genomic data that was generated in this monumental effort. Now this data can be converted into functional data that may be focused directly on the greatest health care needs of the American people: Metabolic Disease.


  • Fast food
  • Processed food
  • 80% of the foods in grocery stores are enhanced with High Fructose Corn Syrup (HFCS)
  • Sugary beverages
  • Energy drinks
  • Diet colas
  • Fried foods
  • Skipping meals
  • Vegetarian/vegan diets are poor in protein and healthy fats


The food and beverage industry is the largest drug addiction program in the world.

  • The beverage industry develops sugary drinks that foment addictive taste disorders.
  • Then they develop energy drinks, combining caffeine and sugar that increase the complexity of addictive disorders, combining addictive taste disorders with addictive energy disorders.
  • Because of the enormous increases in obesity rates, the industry develops “diet colas,” which being totally devoid of any nutrients whatsoever, lead to starvation syndromes that promote metabolic disease.
  • The Food industry develops fast food, which combines the addictive qualities of sugar with the addictive qualities of saturated fat.
  • 80% of the foods in the grocery store have sugar or high fructose corn syrup added to them to enhance taste.
  • The development of trans-fat was a boon to increased shelf life, but nearly destroyed America with enormous increases in heart disease


  • Sugar and fat-rich foods are insatiable and addictive
  • Further, these fast foods minimize protein intake in the diet leading to a malnourished state called “Selective Protein Deficiency Syndrome.”
  • The Paradox of the Modern American Diet (MAD) is that it is rich in calories but poor in essential nutrients, including essential amino acids.


  • The Pharmaceutical Mantra: Develop billion-dollar drugs. What could be better than to develop addictive drugs to treat diseases.
  • The more addictive the drug the more income it will generate.
  • The pharmaceutical industry would rather develop ineffective drugs that perpetuate chronic degenerative diseases forever than cure anyone of these diseases.
    • The pharmaceutical industry was started with cocaine, the wonder drug in the late 19th
    • Statins drain the body of cholesterol, which is necessary for memory, cognitive skills, and brain health and have little or no effect on HDL or Triglyceride levels
    • Anticancer drugs like Avastin are ultra-expensive, yet vastly limited in efficacy, measured in 1 to 2 months..
    • As methamphetamines, Ritalin, Adderall and Vyvance will greatly increase drug addiction disorders in children, teenagers and young adults without adequately treating ADD/ADHD disorders.
    • Pain medications like Oxycontin are highly addictive. In fact pain-relief opioids are now more popular than traditional drugs like Heroin, morphine, cocaine, and crack.
    • Drug addictions are treated with long-acting morphine analogs, Methadone and Buprenorphine that perpetuate the addictive disorders.
    • There is a huge movement to legalize Marijuana, which is highly addictive and leads to smoking-related disorders.
    • Anti-depressants, anti-anxiety, and sleeping pills are highly addictive.
    • Steroids like prednisone in high doses are addictive, fattening, toxic, and even suicidal.

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Disclaimer: This product is not meant to diagnose, treat, cure, or prevent any disease by the use of pharmaceutical drugs. As a dietary supplement, with all natural ingredients, considered to be “generally regarded as safe” (GRAS), Factor4 is intended only to improve health and wellness in the organs and tissues throughout the body. Comments and notations, derived from testimonials and limited human studies, have not been evaluated by the FDA. All results stated in this white paper and on our website(s) are actual results from real customers or individuals included in our clinical trials. Individual results may vary depending on personal goals and use.