Factor4 Health Story

6. The Factor4 Health Story
George A. Scheele, M.D.
December 15, 2015


America’s Health Plummets

Since 1980 the prevalence of obesity and type 2 diabetes have doubled and tripled, respectively, and the prevalence of morbid obesity has sextupled in the US and similar trends are now seen throughout the world.

In 2012 The Institute of Medicine and the National Research Council conducted a study comparing longevity, behavior, and disease among 17 wealthy countries around the world. The current findings concerning the “US Health Disadvantages” are stark. In 1950 the US scored number one in longevity for both men and women. In 2012 the US scored last for men and next to last for women. For chronic degenerative disease the US ranked near the bottom in almost every health sector.

Recent breakthroughs in science by Dr. Scheele and his coworkers have shown that nutritional factors play a more significant role in the spread of metabolic disease than genetic variations. Diet-related diseases, including obesity, type2 diabetes, hypertension, cardiovascular disease, cancer, osteoarthritis, gallbladder, liver and kidney disease, autoimmune diseases, and age-related Alzheimer’s disease affect more than 200 million Americans and account for up to $2 Trillion in health-care costs in the United States on an annual basis.

The Immensity of Obesity and Associated Diseases

At the heart of obesity is its association with an estimated 70% of diseases treated in the field of internal medicine.

The market size for overweight disorders, obesity and the complications of metabolic disease in the United States is enormous, as shown in the table below.

Disease Incidence in adult population in US
Overweight disorders 150 million
Obesity, Class I, II, III 75 million
Prediabetes with elevated fasting blood sugar 80 million
Type 2 Diabetes with elevated blood sugar and Hgb A1c 25 million
Lipid Disorders with elevated triglycerides, cholesterol, LDL and LDL/HDL 30 million
Hypertension with elevated blood pressure 34 million
CVD with elevated blood pressure and C-reactive Protein 57 million

New Discovery Platform

Dr. Scheele has invented a discovery platform that utilizes evolutionary biology to understand how 20,000 proteins work together effectively to enable healthy growth and metabolism in the body rather than the Pharma model that focuses on one chemical agent at a time and produces pharmaceutical drugs normally associated with unhealthy side effects.

With more than 22 Business Development Models defined for Factor4 Weight Control® and a long list of Product Extensions in the pipeline to treat other chronic degenerative diseases, NovaLife, Inc. is in the enviable position to define a new pathway for developing multiple Health-Care Products with reasonable price points to improve world health over the next millennium.

Innovative Technology

Factor4 Health is central to weight control and metabolic health, particularly as we age. Factor4 Weight Control® is a powder that is mixed with water, low fat almond milk or yogurt to make a delicious vanilla praline shake or smoothie. Factor4 consists of all-natural, active ingredients that are considered generally regarded as safe (GRAS) by the FDA.

Factor4 is built on innovative technologies that suppress appetite and restore metabolism using natural feedback mechanisms related to Power Amino Acids®. With patent protection and a unique proprietary formula Factor4 tames appetite and balances metabolism by correcting deficiencies in positive-charged amino acids, proteins and metabolic pathways.

In technical terms we refer to our innovative technology as Accelerated Amino Acid Delivery or AAADT. The importance of this technology is that it can deliver amino acids to the body more than 10-times faster than conventional protein powders and this makes all the difference in normalizing health.

Power Amino Acids® ensure weight-loss health by exploiting the body’s natural feedback mechanisms to:

  • Tame appetite to avoid food cravings
  • Burn fat to lose excess body weight
  • Build muscle to improve body definition
  • Boost Energy to tackle life with vitality

Power Amino Acids® comprise a proprietary blend of essential, positive-charged, and satiety amino acids, which enable the following bonuses:

  • Healthy Lifestyles with increased satiety, improved diet, exercise, sleep, attitude, and less dependency on sugar, caffeine and alcohol.
  • Weight Control with lower body weight, improved body definition, and increased pep, energy, activity, stamina, endurance and performance.
  • Metabolic Health with lower levels of blood cholesterol, triglycerides, sugar and less metabolic disease, including overweight disorders, hypertension, type 2 diabetes, cardiovascular disease, cancer, osteoarthritis, and gallbladder, liver & kidney disease.
  • Anti-Aging Health with increased longevity and quality of life evidenced by reduced chronic degenerative disease and enhanced feelings of comfort, satisfaction, and well-being.

Factor4 Improves Outcomes For Obesity

Factor4 Weight Control® with essential, positive-charged and satiety amino acids (Power Amino Acids®) has been shown to improve results and ensure weight loss success compared with other weight loss strategies, including popular diets, weight loss programs, meal programs or weight loss products.

In 2007 NovaLife conducted a one year open-label clinical trial on Factor4 Weight Control® in 25 obese subjects. Twenty four of these subjects (96%) lost significant amounts of weight within the first 3 months and continued to lose weight as shown in the table below. Results are statistically significant at p<0.01.

Endpoints 3 months 6 months 12 months
Weight loss in pounds 8.4 lbs. 16.2 lbs. 33.4 lbs.
Weight loss in
% body weight
4.5% 8.2% 16.2%

As the FDA requires a 5% reduction in body weight over 12 months to justify weight loss claims, Factor4 exceeds this threshold level by more than 3-times and outpaces all of the drugs that are being developed by biotechnology companies to treat obesity. With refinements in the Factor4 regimen described below, we can now routinely take 100 pounds off a 300 pound man, which equates to a 33% loss in body weight.

Between 2008 and 2012 we refined our treatment protocols and now understand how to normalize body weight in all age groups, both genders, and all body mass levels from BMI values of 25 to over 50. We have increased weight loss results up to 33% in patients with morbid obesity. In more than 5,000 unique patients we have now achieved therapeutic proof-of-concept for Factor4 Weight Control®. We have learned that when patients fail to achieve their desired weight, it is essential that we provide concierge medical services through “teledocing” channels to break through treatment plateaus.

Customer Testimonials

Our website at https://factor4health.com/video-gallery-page-19/chapter/4 has a Video Gallery with testimonials from customers, including Judge Andrew Napolitano, the legal expert for Fox News TV, who lost 75 pounds in 6 months. There are also 11 video presentations of Dr. Scheele talking about the multiple benefits of Factor4 and a 3D animation video that summarizes the effects of Factor4 on the appetite center of the brain and the fat cells in the body. Our customer reviews on the website are unreserved in their strong allegiance to Factor4 Weight Control®.

Factor4 Blogsite

Our blogsite at https://blog.factor4health.com, is one of the best on the internet. (It contains the following components: i) Quick Start Guide, (ii) Weight Loss Guide, (iii) Priming Period Guide, (iv) Recipes for Factor4 Shakes and Smoothies, (v) Blog Posts (n=30), (vi) Monitoring Success containing 9 Articles, rich in weight loss tips (vii) Dr. Scheele Articles on the beneficial effects of Factor4 and the science behind the discovery (24 articles in all) and (viii) Video Testimonials, (ix) Dr. Scheele video slide presentations and (x) How-To-Order Videos.

Outcomes for Obesity, Diabetes & Cardiovascular Disease

The real surprise that emerged from patients taking Factor4 multiple times daily was the dramatic positive effects that were seen in people with chronic degenerative disorders and metabolic risk factors for metabolic diseases. For example, in diabetic patients Factor4 reduced fasting blood sugar levels by 35 to 50% within the first 10 days before significant weight loss had occurred. Once significant weight loss was achieved, their blood sugar levels dropped even further.

In cardiovascular patients who take Factor4 Weight Control® LDL cholesterol levels have been decreased and HDL cholesterol levels have been increased, allowing these patients to minimize or avoid statin drugs that may have serious adverse effects on muscle and liver tissue with a 25% incidence of harmful side-effects. C-Reactive Protein levels have been significantly reduced leading to reduced vascular inflammation. Blood pressure levels have been reduced and blood flow to peripheral tissues has increased, resulting in noticeable enhancements in peripheral pulses, in growth of hair and nails and in improvements in skin color and elasticity.

Factor4 also builds muscle tissue and increases energy, stamina and endurance in normal people as well as athletes who engage in extreme sports.

All in all Dr. Scheele has been able to record 20 general health benefits of Factor4 and up to 50 different ways that patients may feel better in the eight major consumer health systems of the body: (i) body weight and energy, (ii) beauty health (hair, skin and nails), (iii) Mental balance/health, (iv) digestive health, (v) metabolic health, (vi) immune health, (vii) sexual and reproductive health and (viii) anti-aging health.

When taken correctly Factor4 protects against diet- and age-related disorders that lead to metabolic diseases like obesity, type 2 diabetes and cardiovascular disease, including their complications (hyperglycemic and hypoglycemic attacks, heart attacks, strokes, kidney disease, and blindness) that require emergency room visits, hospitalizations, acute care, post-acute care, outpatient care, long-term care and in many cases hospice care.

When viewed in the light of the above-listed conditions, the cost of Factor4 is miniscule in comparison to the much larger costs of the diet- and age-related diseases listed above.

For every patient who achieves normal body weight, body mass index, body composition endpoints, and metabolic risk factors (medical outcomes) it removes that patient from the group of patients, who untreated, will show the potential for developing the numerous complications of obesity that lead to expensive drugs, procedures, prosthetics and life-sustaining measures that define these diseases.

Far better than the outcomes associated with expensive chronic therapeutic agents like diabetes medications (oral agents, insulin, GLP-1 drugs), antihypertensive medications (diuretics, calcium channel blockers, angiotensin inhibitors, ACE and ARB), and ischemic heart disease medications (digitalis, beta blockers, blood thinners, nitroglycerin) is the opportunity to provide therapeutic interventions that treat the root cause of the attendant diseases.

Patent Protection:

Because the science behind Factor4 is unique, the product has recently received three issued patents:

  • US Patent No. 7,982,066 B2 issued on 7-19-11 (Utility Patent)
  • US Patent No. 8,362,297 B2 issued on 1-29-13 (Composition Patent)
  • US Patent No. 8,779,189 B2 (Power Amino Acids® in capsules)


  • NovaLife®
  • Power Amino Acids®
  • Factor4 Weight Control®

Factor4 Weight Control Websites:

Factor4 10-Times Better Than Protein Powders or Diets in Accelerating Amino Acid Delivery to the Body

In a market brimming with generic protein products why did Dr. Scheele formulate Factor4 Weight Control® as an amino acid powder with backup protein rather than as a simple protein powder? The short answer is that Factor4 Weight Control® is more than 10 times better in delivering essential amino acids to the body compared to generic protein powders and diets. Essential amino acids drive satiety, weight loss, metabolic health and anti-aging.

Protein powders have never been shown, in clinical studies, to work beneficially as weight loss products. This is why the FDA has never allowed any of the protein products to market “hard” claims related to weight-loss health. In contrast, Factor4 Weight Control® has helped more than 5,000 customers to lose weight. Since Factor4 contains protein, what is the difference in efficacy between the two products? The difference is that Factor4 contains a rich source of free essential amino acids (Power Amino Acids®) which do not require digestion and therefore are rapidly absorbed into the body within 10 to 60 minutes. When elevated in the blood stream, these amino acids signal satiety to the appetite centers in the brain and intestinal tract and therefore minimize food intake.

Furthermore, Power Amino Acids® in Factor4 stimulate the digestive process (secretion of pancreatic enzymes and contraction of the gallbladder) by up to 10 times, which increases the digestion and assimilation of “backup” protein in the product.

The International Nutrition Research Center (INRC) has extensively studied the utilization of protein-bound amino acids and confirmed these findings. They report that the net nitrogen utilization (absorption of amino acids) from generic protein powders average 17%. This means that 83% of the amino acids in protein powders are passed through the body as waste. Furthermore the 17% of amino acids that are released through the digestive process are released slowly with a mean absorption time of 4 hours for Whey protein and 8 hours for Casein protein. This means that the beneficial effects of protein-bound amino acids in protein powders are greatly limited and in most cases undetectable.

Protein Powder Assimilation Over Time

By comparison, free amino acids like Power Amino Acids®, delivered in the diet, are rapidly absorbed by the intestinal tract and utilized by the body at levels which approach 99%. Thus, free amino acids show NNU levels that are 10 times more efficient than protein-bound amino acids contained in protein products.

The Figure above shows the simulated time-course and quantity of absorption of free amino acids from Factor4 Weight Control® compared to generic protein powders like Whey and Casein. The schematic diagrams explain why Factor4 Weight Control® is more than 10 times better than generic protein powders, meal programs or diet plans in delivering essential amino acids to the body. Since essential amino acids drive satiety, weight loss, metabolic health and healthy aging, we can now understand why Factor4 demonstrates so many benefits not seen in other weight loss solutions.

Nonprofit Institute to Improve World Health (501c3)

We believe it will be easier to raise significant funds for multiple sequential clinical trials for product extensions that treat other chronic degenerative diseases listed above through a non-profit 501c3 organization because of the tax write-offs for contributions to a 501c3 organization.

In May, 2015 the non-profit organization received tax exempt status from the IRS. Hence the non-profit organization is now in a position to receive tax-free donations.

Upon request the following documents related to the non-profit organization are available for review:

  • The Vision Statement
  • The Strategy Statement
  • The Operational Plan

New Product Development

Over the same period of time we will initiate development of a new product called “Factor4 Fitness Health,” for the teenage and adult audience, both for males and females. Because packaging is a critical component of success in retail products, we will hire marketing professionals to design a new label for this age group

We believe that Accelerated Amino acid Delivery Technology (AAADT) will achieve booming sales with young men and women who want to increase their fitness goals and reach them more quickly. As part of this program we will identify two or more exercise physiologists in the fitness industry to consult in our marketing efforts to this younger demographic group.


NovaLife, Inc.is located at 7825 Fay Avenue, suite 200, La Jolla, California.

NovaLife has been in business since 2000 as a C Corporation. After R&D activities, Factor4 Weight Control® was formulated in 2005. Our clinical weight loss study was performed over 12 months in 2007. Since that time, our internet e-commerce business has expanded across America and around the world, most notably in Australia, Canada, and Europe. NovaLife is a profitable company and sales have increased more than 10-times from 2010 to 2014.

Senior Personnel

George A. Scheele, M.D., Founder, President and CEO,

Dr. George A. Scheele is a world-renowned physician, inventor, author and two-time Nobel Associate, who has pioneered in understanding the critical role of amino acids in regulating metabolic health and body weight. He recently introduced Factor4 Weight Control® with essential ingredients to treat the four nutritional traps that lead to overweight disorders and obesity.

As a graduate of Princeton University and Johns Hopkins Medical School Dr. Scheele worked with two Nobel Prize teams at the Rockefeller University, including George E. Palade, who received the Nobel Prize in Medicine in 1974 and Gunter  Blobel, who received the Nobel Prize in Medicine in 1999. Dr. Scheele contributed substantially to both prizes.

Dr. Scheele served as Professors of Medicine on the faculties of The Rockefeller University, Yale University School of Medicine and Harvard Medical School. Dr. Scheele invented new concepts and techniques which “cracked the code” in understanding how Power Amino Acids® correct the deficiencies in amino acids, positive-charged proteins, and metabolic pathways that restore normal metabolism and body weight.

In 2011 Dr. Scheele published The Obesity Cure, which summarized his scientific achievements over the past 40 years that impact on obesity and metabolic disease. Using a lifetime of scientific achievement and clinical insight, Dr. Scheele explains how to use nature’s gift – Power Amino Acids –to avoid “addictive taste disorders” and harness the body’s own feedback mechanisms to tame appetite, rebalance metabolism, and normalize body weight.

This book discusses five main topics:

  1. The success and failure of dietary studies over the past 100 years
  2. Adaptive changes and energy pathways involved in control of appetite and metabolism.
  3. The Metabolic Syndrome, aging, and the paradoxes of nutritional disease and weight control.
  4. Selective Protein Deficiency Syndrome as a general theory of nutrition that can explain the enormous rise in diet-related diseases like Obesity and the Metabolic Syndrome.
  5. The role of dietary health in human destiny.

Dr. Scheele’s career is explained in greater detail at www.drgeorgescheele.com.

Confidential Document: All rights reserved. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any other information storage and retrieval system, without the written permission of the publisher.

Disclaimer: This product is not meant to diagnose, treat, cure, or prevent any disease by the use of pharmaceutical drugs. As a dietary supplement, with all natural ingredients, considered to be “generally regarded as safe” (GRAS), Factor4 is intended only to improve health and wellness in the organs and tissues throughout the body. Comments and notations, derived from testimonials and limited human studies, have not been evaluated by the FDA. All results stated in this white paper and on our website(s) are actual results from real customers or individuals included in our clinical trials. Individual results may vary depending on personal goals and use.