Selective Protein Deficiency in the Pathogenesis of Chronic Degenerative Disease & Aging
George A. Scheele, M.D.
Posted on
December 15, 2015



We have identified protein candidates that appear to be responsible, in large part, for the diet-related development of (i) obesity, (ii) Type-2 diabetes, (iii) pancreatitis, (iv) toxin-induced liver cancer, (v) colon cancer, (vi) cancers due to loss of DNA repair and P53 tumor suppression, (vii) aging syndromes, (viii) telomere dysfunction leading to premature aging, (ix) age-related sarcopenia (x) Dementia syndromes and (xi) anandamide regulation of well-being and procreation.

Our research has also provided insight into how to prevent and treat these nutritional defects.

George A. Scheele, M.D.
December 15, 2015

The Most Urgent Need:

The most urgent need in Health and Medicine today is to conquer the chronic degenerative diseases that are associated with the Metabolic Syndrome including overweight disorders, type-2 diabetes, lipid disorders, cardiovascular disease, dementia, Alzheimer’s disease and premature aging. In this website Dr. Scheele provides answers to the most pressing questions about these conditions.

The Breakthrough:

Factor4 Health represents a breakthrough in Evolutionary Medicine which utilizes new aspects of evolutionary theory to explain the rise in chronic degenerative diseases associated with the Metabolic Syndrome and how to beneficially treat these diseases with Accelerated Amino Acid Delivery Technologies (AAADT). The novel biological concepts reported here depend upon the extraordinary accomplishments of Dr. Scheele in Clinical Medicine and Basic Science Research over the past 45 years

In 1975 Dr. Scheele invented 2D gel electrophoresis that allowed the first detailed analysis of protein synthesis in individual tissues according to the size and charge of each protein (1). Detailed nutritional studies in rats in the 80s and 90s, analyzed by 2D gel electrophoresis, showed that decreased levels of dietary protein (15% to 0% of daily calories) resulted in the progressive loss in the synthesis of positive-charged proteins in the exocrine pancreas and throughout the body (2). These studies identified, for the first time, a considerable vulnerability in the synthesis of positive-charged proteins, rich in Lysine [K] and Arginine [R] residues, due to poor nutrition. This unique observation has been called Selective Protein Deficiency Syndrome by Dr. Scheele in his 2011 book, entitled The Obesity Cure (3).

Food chain signals are intimately involved in the evolution of vertebrates and mammals as they control the feedback mechanisms of hunger and satiety, which are important in reproduction and evolution. Without understanding the importance of hunger and satiety signals modern societies will suffer from epidemics of diet-related metabolic disease, including obesity, type 2 diabetes, lipid disorders, cardiovascular disease, brain disease, autoimmune disorders, and cancer.

The La Jolla Project has already identified specific KR-rich proteins with high isoelectric points (pI values) that appear to be vulnerable to a dietary deficiency of essential and positive-charged amino acids and further determined the presumed molecular pathogenesis for how the loss of these proteins from the expressed proteome will lead to the corresponding metabolic disease, whether that be type-2 diabetes, obesity, Alzheimer’s disease, pancreatitis, cancer or aging.

In this body of work, Dr. Scheele has discovered new relationships between (i) Evolution, (ii) Natural Selection (iii) Molecular Biology, (iv) Proteomics and (v) Metabolic Health. The new discoveries are compatible with the theories of Evolution, Natural Selection through survival of the fittest, and the importance of essential amino acids in fitness, metabolic health and longevity. This innovative effort establishes a new field of dietary genomics and proteomics capable of defining a new field of nutritional pathology, called the “Nutritional Pathosome.”

The themes behind these novel biological concepts are described in greater detail in the following articles, which may be examined below:

  1. Breakthrough Science in Chronic Degenerative Disease & Aging
  1. Food Chain Signals Determine Hunger and Satiety, Sickness and Health
  1. Evolution Theory and the Biology of Aging and Chronic degenerative Disease
  1. Primer on Amino Acids in Protein Synthesis related to Evolutionary Theory & Natural Selection
  1. A Commentary on George A. Scheele, M.D.
  1. The Factor4 Health Story
  1. Factor4 Health: The Breakthrough in Chronic Degenerative Disease & Aging

These articles provide scientific details in the publication of novel biological concepts that explain Evolutionary Theory and the Role of Selective Protein Deficiency in Chronic Degenerative Disease and Aging in Humans. As part of these publications Dr. George A. Scheele describes, for the first time:

  • A Unified Theory for the Selective Loss of Proteins due to Poor Nutritional Diets.
  • The Elucidation of Hunger and Satiety Signals Related to the Absence and Presence of Essential Amino Acids (EAAs), respectively, in the Appetite Center (Arcuate Nucleus) of the Hypothalamus.
  • A Unified Theory which Explains the Role of essential amino acids (EAA), semi-essential amino acids (SEAA) and non-essential amino acids (NEAA) in Evolutionary Theory Related to Higher Animals Including Humans
  • Why essential amino acids (EAA) are not made in the body
  • Why semi-essential amino acids (SEAA) are not made in the body under conditions of a Poor Nutritious Diet
  • Specific Positive-Charged Proteins that appear to be Vulnerable in a Poor Nutritious Diet Resulting in a Loss of these Proteins in Human Tissues.
  • The Functions of These Positive-Charged Proteins that Appear to Explain the Pathogenesis of Specific Chronic Degenerative Diseases, Including:
    • Overweight Disorders & Obesity
    • Type-2 Diabetes
    • Lipid Disorders
    • Cardiovascular Disease
    • Cancer
    • Brain disorders including Dementia and Alzheimer’s Disease
    • Premature Aging
  • The Relationship Between a Decrease in Positive-Charged Proteins to the Loss of Functions in Chronic Degenerative Diseases, including Obesity, Type-2 Diabetes, Lipid Disorders, Arteriosclerosis and neurological changes due to dementia, Alzheimer’s Disease and More.
  • Designed a Technology (AAADT) and a Product (Factor4 Weight Control®) Capable of Accelerating the Delivery of Essential Amino Acids to the Human Body, which is more than 10x Superior to Generic Protein Powders.
  • Conducted a 12 month Clinical Study on the Beneficial Effects of this Technology in the Treatment of Overweight Disorders.
  • Explains How Accelerated Amino Acid Delivery Technologies (AAADT) and Products:
    • Prevent Selective Protein Deficiency Syndrome which Rebalances Metabolic Pathways to Rebuild the Body
    • Reduce Appetite to Normalize Body Mass Index
    • Rebalance Carbohydrate Metabolism to Combat Insulin & Leptin Resistance
    • Improve Vascular Health and Cardiovascular Functions
    • Improve DNA Repair to Help Prevent Cancer
    • Improve Telomere Health in Aging
    • Improve Brain Functions in Dementia
    • Improve Anandamide Functions in Procreation, optimizing Copulation, Fertilization, Implantation of the Fertilized Egg, Pregnancy, Birth, Breast Feeding and Child Development
  • Why Current Clinical Assessments of Protein Levels in Human Blood Samples, including Albumin and Globulin, are incapable of Diagnosing Early Forms of Protein Deficiency in the body.

The Foundation and Institute to Improve World Health

Our 501c3, Foundation and Institute to Improve World Health, will raise $50 to $100 million to accomplish the following:

The La Jolla Project:

  • Conduct basic science efforts to convert the entire human genome and proteome into a “Nutritional Pathosome” indicating the rank-file order in which we anticipate human proteins will become vulnerable (disappear) during poor nutritional health, defined as a diet deficient in essential and positive-charged amino acids.
  • Link the disappearance of positive-charged proteins with the pathogenesis of individual human metabolic diseases (chronic degenerative diseases and aging).
  • Define all the metabolic pathways in the human body and highlight those enzymes that are vulnerable to a poor nutritious diet, as defined above.
  • Develop an Annual Meeting for Evolution Theory and the Biology of Chronic Degenerative Disease and Aging to be held in La Jolla, CA.

Clinical Trials:

  • Support FDA clinical trials as described above for individual chronic degenerative diseases.

The Vision Statement, the Strategy Statement and the Operational Plan for the 501c3 organization are available for review upon signing a Confidentiality Agreement.


  1. Scheele, G. (1975) Two-dimensional gel analysis of soluble proteins – Characterization of guinea pig exocrine pancreatic proteins. J. Biol. Chem. 250: 5375-85.
  1. Schick, J., Verspohl, R., Kern, H. and Scheele, G. (1984) Two distinct genetic patterns of response in the exocrine pancreas to inverse changes in protein and carbohydrate in the diet, Am. J. Physiol. 248: G611-616.
  1. Scheele, G. The Obesity Cure (2011) Published by Bookmasters, Ashland, OH.
  1. Scheele’s complete bibliography may be reviewed on his career website at



Dr. Scheele would like to express his gratitude to the many coauthors that appear in his publications from 1974 through 2011. Special thanks go to his long-time collaborators, including Professor Horst Kern at the Philipps University in Marburg, Germany, who supervised the dietary studies in rats and Dr. Shin-Ichi Fukuoka, Professor of Molecular & Cell Biology, Aoyama Gakuin University, Japan, who provided the amino acid sequences for the proteins included in this body of work as well as his sage counsel.